منابع مشابه
Targeting Kv7 channels in pain pathways
The K v 7 family of potassium channels, formerly known as KCNQ, is composed of five members numbered from 1 to 5. K v 7 subunits 2 to 5 are expressed in neurons where they give rise to voltage dependent potassium currents (M-or M-like currents or I M) with interesting properties, including slow activation kinetics with no inactivation upon depolarization and a complex modulation by an array of ...
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Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour. Of the myriad ion channels present in the uterus, this article will focus upon potassium channels encoded by the KCNQ genes and ether-à-go-go-related ...
متن کاملP 46: The Role of Kv7-Channels in the Pathophysiology of Multiple Sclerosis
Multiple sclerosis is an autoimmune CNS-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. Recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. The latter is a transitory condition that, very likely, leads to impaired neuronal networ...
متن کاملKV7/KCNQ Channels Are Functionally Expressed in Oligodendrocyte Progenitor Cells
BACKGROUND K(V)7/KCNQ channels are widely expressed in neurons and they have multiple important functions, including control of excitability, spike afterpotentials, adaptation, and theta resonance. Mutations in KCNQ genes have been demonstrated to associate with human neurological pathologies. However, little is known about whether K(V)7/KCNQ channels are expressed in oligodendrocyte lineage ce...
متن کاملKv7 channels regulate pairwise spiking covariability in health and disease.
Low-threshold M currents are mediated by the Kv7 family of potassium channels. Kv7 channels are important regulators of spiking activity, having a direct influence on the firing rate, spike time variability, and filter properties of neurons. How Kv7 channels affect the joint spiking activity of populations of neurons is an important and open area of study. Using a combination of computational s...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2020
ISSN: 1664-042X
DOI: 10.3389/fphys.2020.00634